Biological sciences
Elaheh Gholami Roudmajan; Ali H. Al-Marzoqi; Miaad K. Alkhudhairy; Maryam Kohansal; Abdolmajid Ghasemian; Seyed Masoud Houshmand
Abstract
A leading risk factor for cervical cancer (CC) initiation and progress includes human papillomavirus (HPV) infection. The telomerase catalytic subunit which regulates senescence and proliferation (carcinogenesis) is encoded by human telomerase reverse transcriptase (hTERT) gene. Our objective was the ...
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A leading risk factor for cervical cancer (CC) initiation and progress includes human papillomavirus (HPV) infection. The telomerase catalytic subunit which regulates senescence and proliferation (carcinogenesis) is encoded by human telomerase reverse transcriptase (hTERT) gene. Our objective was the assessment of high risk HPV genotypes (16, 18 and 31) association with two polymorphisms of hTERT gene (rs2736098 and rs2736100) in CC development. Forty CC specimens were retired and 49 blood samples from healthy individuals were used as control group. The PCR-RFLP was performed for the detection of rs2736098 and rs2736100 polymorphisms. The differences of A, C or G alleles were not significant between case and control. Accordingly, among 10 high risk HPV genotypes, genotype 18 was detected and there was no meaningful relation between neither the hTERT rs2736098 nor the rs2736100 polymorphisms and CC risk.
Biological sciences
Manal Hadi Ghaffoori Kanaan; Hiba Riyadh Al-abodi; Sura Saad Abdullah; Mojtaba Memariani; Maryam Kohansal; Abdolmajid Ghasemian
Abstract
In this study, fifty Moraxella species were isolated. The antibiotic susceptibility, β-lactamases and minimum inhibitory and bactericidal concentrations were evaluated. The rate of ESBLs among M. catarrhalis, M. osloensis and M. lacunata included 47 % (n=11), 36.84 % (n=7) and 37.5 % (n=3), respectively. ...
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In this study, fifty Moraxella species were isolated. The antibiotic susceptibility, β-lactamases and minimum inhibitory and bactericidal concentrations were evaluated. The rate of ESBLs among M. catarrhalis, M. osloensis and M. lacunata included 47 % (n=11), 36.84 % (n=7) and 37.5 % (n=3), respectively. The strong biofilm formation was observed among 52 %, 63.5 % and 62.5 % of M. catarrhalis, M. osloensis and M. lacunata, respectively. The rate of the bro1, bro2 and blaCTX-M1 genes in M. catarrhalis included 23/23 (100 %), 12/23 (52.17 %) and 5/23 (21.8 %), respectively. Moreover, 14/19 (73.68 %), 8/19 (42.10 %) and 2/19 (10.52 %) of M. osloensis, respectively contained these genes. The bro1 gene was detected in all the M. lacunata isolates. Moraxella spp highly produced BRO β-lactamases and ESBLs, and deciphered strong biofilm formation.
